GL1X · GenesisL1 explorer

Research workbench

Protein tyrosine phosphatase (putative) from leishmania major

Analyse Protein tyrosine phosphatase (putative) from leishmania major in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3S4O
Type
protein
Length
326 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Protein tyrosine phosphatase-like protein
EC
3.1.3.48
UniProt
Q4QEZ7
Ligands
THJ
Pockets
1 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, BProtein tyrosine phosphatase-like protein (EC 3.1.3.48)protein16342% helix, 18% strandQ4QEZ7

Ligands and binding sites

  • THJ · Thiosulfate · ligand · chains A
  • EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
12180.540.7839empty

Interfaces

1 interface between chains.

  • A–B · 922 Ų buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified, 1 disulfide (engineered, disulfide).

Compared structures

  • 3S4O · Protein Tyrosine Phosphatase (putative) from Leishmania major · the same entry in another collection · chain A against A, TM-score 1.00
  • Q4QEZ7 · AlphaFold monomer V2.0 prediction for protein tyrosine phosphatase prl-1 (Q4QEZ7) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.