Research workbench
MEOS2 fluorescent protein-green form
Analyse MEOS2 fluorescent protein-green form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3S05
- Type
- protein
- Length
- 877 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Green to red photoconvertible gpf-like protein eosfp
- UniProt
- Q5S6Z9
- Ligands
- CR8
- Pockets
- 11 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 5% helix, 56% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Green to red photoconvertible gpf-like protein eosfp | protein | 220 | 5% helix, 56% strand | Q5S6Z9 |
| B | Green to red photoconvertible gpf-like protein eosfp | protein | 221 | 5% helix, 56% strand | Q5S6Z9 |
| C, D | Green to red photoconvertible gpf-like protein eosfp | protein | 218 | 6% helix, 57% strand | Q5S6Z9 |
Ligands and binding sites
- CR8 · 2-[1-amino-2-(1H-imidazol-5-yl)ethyl]-1-(carboxymethyl)-4-[(4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-1H-imidazol-5-olate · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1104 | 0.81 | 0.83 | 80 | empty |
| 2 | 78 | 0.75 | 0.98 | 24 | CR8 |
| 3 | 70 | 0.74 | 0.98 | 26 | CR8 |
| 4 | 72 | 0.73 | 0.98 | 26 | CR8 |
| 5 | 71 | 0.73 | 0.98 | 25 | CR8 |
Interfaces
5 interfaces between chains.
- A–B · 1358 Ų buried · 27 hydrogen bonds · protein-protein
- C–D · 1336 Ų buried · 25 hydrogen bonds · protein-protein
- A–C · 912 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 897 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 37 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 covalent (covalent ligand).
Compared structures
- 3S05 · mEos2 Fluorescent Protein-Green Form · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5S6Z9
- Elsewhere: RCSB PDB 3S05 · PDBe 3S05 · UniProt Q5S6Z9
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