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Structure of P450PYR hydroxylase

Analyse Structure of P450PYR hydroxylase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3RWL
Type: protein
Length: 404 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome P450 alkane hydroxylase 1 CYP153A7
EC: 1.14.15.3
UniProt: Q5F4D9
Ligands: HEM
Pockets: 3 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome P450 alkane hydroxylase 1 CYP153A7 (EC 1.14.15.3)	protein	404	52% helix, 11% strand	Q5F4D9

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	803	0.78	0.81	80	HEM
2	56	0.30	0.75	13	empty
3	57	0.29	0.75	16	empty

Compared structures

3RWL · Structure of P450pyr hydroxylase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5F4D9
Elsewhere: RCSB PDB 3RWL · PDBe 3RWL · UniProt Q5F4D9

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