Research workbench
Rhesus macaque MHC class I molecule mamu-B*17-HW8
Analyse Rhesus macaque MHC class I molecule mamu-B*17-HW8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3RWJ
- Type
- protein
- Length
- 384 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major histocompatibility complex class I; Beta-2-microglobulin; Vif HW8 peptide from…
- UniProt
- Q9GJ77, P61769, Q89490
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major histocompatibility complex class I | protein | 276 | 25% helix, 39% strand | Q9GJ77 |
| B | Beta-2-microglobulin | protein | 100 | 0% helix, 48% strand | P61769 |
| C | Vif HW8 peptide from virion infectivity factor | protein | 8 | 0% helix, 0% strand | Q89490 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 583 | 0.69 | 0.78 | 57 | empty |
| 2 | 50 | 0.54 | 0.89 | 13 | empty |
| 3 | 140 | 0.47 | 0.78 | 24 | empty |
| 4 | 62 | 0.36 | 0.78 | 14 | empty |
| 5 | 60 | 0.35 | 0.78 | 17 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1418 Ų buried · 23 hydrogen bonds · protein-protein
- A–C · 932 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9GJ77
- Every structure of UniProt P61769
- Every structure of UniProt Q89490
- Elsewhere: RCSB PDB 3RWJ · PDBe 3RWJ · UniProt Q9GJ77 · UniProt P61769 · UniProt Q89490
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