Research workbench
Rhesus macaque MHC class I molecule mamu-B*17-QW9
Analyse Rhesus macaque MHC class I molecule mamu-B*17-QW9 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3RWF
- Type
- protein
- Length
- 385 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Major histocompatibility complex class I; Beta-2-microglobulin; Nef QW9 peptide from…
- UniProt
- Q9GJ77, Q6V7J5, Q5QGG3
- Pockets
- 5 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Major histocompatibility complex class I | protein | 276 | 25% helix, 40% strand | Q9GJ77 |
| B | Beta-2-microglobulin | protein | 100 | 0% helix, 49% strand | Q6V7J5 |
| C | Nef QW9 peptide from protein nef | protein | 9 | 0% helix, 0% strand | Q5QGG3 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 591 | 0.70 | 0.79 | 52 | empty |
| 2 | 82 | 0.41 | 0.79 | 22 | empty |
| 3 | 64 | 0.41 | 0.80 | 14 | empty |
| 4 | 94 | 0.40 | 0.77 | 18 | empty |
| 5 | 61 | 0.33 | 0.77 | 18 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1433 Ų buried · 25 hydrogen bonds · protein-protein
- A–C · 996 Ų buried · 18 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9GJ77
- Every structure of UniProt Q6V7J5
- Every structure of UniProt Q5QGG3
- Elsewhere: RCSB PDB 3RWF · PDBe 3RWF · UniProt Q9GJ77 · UniProt Q6V7J5 · UniProt Q5QGG3
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