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Structure of 4C1 Fab in P212121 space group

Analyse Structure of 4C1 Fab in P212121 space group in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3RVT
Type: protein
Length: 435 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fab fragment of 4C1 antibody - light chain; Fab fragment of 4C1 antibody - heavy chain
Pockets: 6 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Fab fragment of 4C1 antibody - light chain	protein	213	6% helix, 52% strand	—
D	Fab fragment of 4C1 antibody - heavy chain	protein	222	5% helix, 50% strand	—

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	592	0.62	0.74	72	empty
2	215	0.54	0.78	31	empty
3	50	0.45	0.86	19	empty
4	63	0.43	0.82	16	empty
5	92	0.35	0.74	24	empty

Interfaces

1 interface between chains.

C–D · 1984 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

3RVT · Structure of 4C1 Fab in P212121 space group · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3RVT · PDBe 3RVT

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