Research workbench
Crystal structure of human lair-1 in C2 space group
Analyse Crystal structure of human lair-1 in C2 space group in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3RP1
- Type
- protein
- Length
- 388 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukocyte-associated immunoglobulin-like receptor 1
- UniProt
- Q6GTX8
- Pockets
- 3 · best druggability 0.83
Structure
x-ray diffraction · 3 distinct chains · 3% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leukocyte-associated immunoglobulin-like receptor 1 | protein | 96 | 3% helix, 55% strand | Q6GTX8 |
| B, D | Leukocyte-associated immunoglobulin-like receptor 1 | protein | 97 | 3% helix, 53% strand | Q6GTX8 |
| C | Leukocyte-associated immunoglobulin-like receptor 1 | protein | 98 | 3% helix, 54% strand | Q6GTX8 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 915 | 0.83 | 0.85 | 120 | empty |
| 2 | 115 | 0.46 | 0.79 | 27 | empty |
| 3 | 122 | 0.39 | 0.75 | 22 | empty |
Interfaces
5 interfaces between chains.
- A–D · 501 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 459 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 452 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 428 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 414 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3RP1 · Crystal structure of Human LAIR-1 in C2 space group · the same entry in another collection · chain A against A, TM-score 1.00
- Q6GTX8 · AlphaFold monomer V2.0 prediction for leukocyte-associated immunoglobulin-like receptor 1… · a predicted model of the same protein · chain C against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6GTX8
- Elsewhere: RCSB PDB 3RP1 · PDBe 3RP1 · UniProt Q6GTX8
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