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Crystal structure of geranylgeranyl pyrophosphate synthase from bacteroides thetaiotaomicron

Analyse Crystal structure of geranylgeranyl pyrophosphate synthase from bacteroides… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3RMG
Type: protein
Length: 596 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Octaprenyl-diphosphate synthase
UniProt: Q8A2P4
Pockets: 6 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Octaprenyl-diphosphate synthase	protein	299	80% helix, 0% strand	Q8A2P4
B	Octaprenyl-diphosphate synthase	protein	297	75% helix, 0% strand	Q8A2P4

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	926	0.81	0.82	87	empty
2	537	0.71	0.80	52	empty
3	200	0.49	0.75	24	empty
4	94	0.38	0.76	18	empty
5	60	0.29	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 1835 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

3RMG · Crystal structure of geranylgeranyl pyrophosphate synthase from bacteroides… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8A2P4
Elsewhere: RCSB PDB 3RMG · PDBe 3RMG · UniProt Q8A2P4

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