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Crystal structure of the middle domain of human PAIP1

Analyse Crystal structure of the middle domain of human PAIP1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3RK6
Type: protein
Length: 434 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polyadenylate-binding protein-interacting protein 1
UniProt: Q9H074
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 77% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Polyadenylate-binding protein-interacting protein 1	protein	217	77% helix, 2% strand	Q9H074

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	299	0.68	0.83	41	empty
2	226	0.55	0.78	27	empty
3	105	0.36	0.74	26	empty
4	75	0.29	0.73	16	empty

Interfaces

1 interface between chains.

A–B · 588 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

3RK6 · Crystal structure of the middle domain of human Paip1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9H074 · AlphaFold monomer V2.0 prediction for polyadenylate-binding protein- interacting protein… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H074
Elsewhere: RCSB PDB 3RK6 · PDBe 3RK6 · UniProt Q9H074

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