Research workbench
Crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens]
Analyse Crystal structure of mutl protein homolog 1 isoform 1 [homo sapiens] in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3RBN
- Type
- protein
- Length
- 504 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA mismatch repair protein MLH1
- UniProt
- P40692
- Pockets
- 4 · best druggability 0.36
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA mismatch repair protein MLH1 | protein | 261 | 46% helix, 18% strand | P40692 |
| B | DNA mismatch repair protein MLH1 | protein | 243 | 51% helix, 18% strand | P40692 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 95 | 0.36 | 0.75 | 16 | empty |
| 2 | 74 | 0.33 | 0.76 | 15 | empty |
| 3 | 77 | 0.32 | 0.74 | 19 | empty |
| 4 | 52 | 0.28 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 807 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 modified (engineered).
Compared structures
- 3RBN · Crystal structure of MutL protein homolog 1 isoform 1 [Homo sapiens] · the same entry in another collection · chain A against A, TM-score 1.00
- P40692 · AlphaFold monomer V2.0 prediction for DNA mismatch repair protein MLH1 (P40692) · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40692
- Elsewhere: RCSB PDB 3RBN · PDBe 3RBN · UniProt P40692
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