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Structure of the first domain of a cardiac ryanodine receptor mutant with exon 3 deleted

Analyse Structure of the first domain of a cardiac ryanodine receptor mutant with exon… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3QR5
Type: protein
Length: 305 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cardiac CA2+ release channel
UniProt: Q9ERN6
Pockets: 1 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 0% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cardiac CA2+ release channel	protein	151	0% helix, 50% strand	Q9ERN6
B	Cardiac CA2+ release channel	protein	154	0% helix, 48% strand	Q9ERN6

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	731	0.69	0.76	60	empty

Interfaces

1 interface between chains.

A–B · 190 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

3QR5 · Structure of the first domain of a cardiac Ryanodine Receptor mutant with exon 3 deleted · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9ERN6
Elsewhere: RCSB PDB 3QR5 · PDBe 3QR5 · UniProt Q9ERN6

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