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Crystal structure of glucose-6-phosphate isomerase (PF14_0341) from plasmodium falciparum 3D7
Analyse Crystal structure of glucose-6-phosphate isomerase (PF14_0341) from plasmodium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3QKI
- Type
- protein
- Length
- 1,724 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucose-6-phosphate isomerase
- EC
- 5.3.1.9
- UniProt
- Q8ILA4
- Pockets
- 18 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 54% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucose-6-phosphate isomerase (EC 5.3.1.9) | protein | 575 | 54% helix, 11% strand | Q8ILA4 |
| B | Glucose-6-phosphate isomerase (EC 5.3.1.9) | protein | 575 | 54% helix, 11% strand | Q8ILA4 |
| C | Glucose-6-phosphate isomerase (EC 5.3.1.9) | protein | 574 | 54% helix, 11% strand | Q8ILA4 |
Pockets
18 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1111 | 0.82 | 0.83 | 72 | empty |
| 2 | 471 | 0.71 | 0.81 | 50 | empty |
| 3 | 506 | 0.71 | 0.81 | 53 | empty |
| 4 | 414 | 0.62 | 0.77 | 55 | empty |
| 5 | 348 | 0.61 | 0.78 | 38 | empty |
Interfaces
1 interface between chains.
- B–C · 6989 Ų buried · 95 hydrogen bonds · protein-protein
Compared structures
- 3QKI · Crystal structure of Glucose-6-Phosphate Isomerase (PF14_0341) from Plasmodium falciparum… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8ILA4
- Elsewhere: RCSB PDB 3QKI · PDBe 3QKI · UniProt Q8ILA4
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