Research workbench
Structure of neurexin 1 alpha (domains LNS1-LNS6), no splice inserts
Analyse Structure of neurexin 1 alpha (domains LNS1-LNS6), no splice inserts in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3QCW
- Type
- protein
- Length
- 2,006 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Neurexin-1-alpha
- UniProt
- Q28146
- Ligands
- NAG
- Pockets
- 10 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 3% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Neurexin-1-alpha | protein | 1003 | 3% helix, 46% strand | Q28146 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1014 | 0.76 | 0.78 | 80 | empty |
| 2 | 1043 | 0.75 | 0.78 | 74 | empty |
| 3 | 279 | 0.59 | 0.78 | 36 | empty |
| 4 | 183 | 0.56 | 0.80 | 41 | empty |
| 5 | 293 | 0.56 | 0.77 | 35 | empty |
Modifications
Observed in the structure: 20 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q28146
- Elsewhere: RCSB PDB 3QCW · PDBe 3QCW · UniProt Q28146
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