Research workbench
Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 2-[(3,4-DICHLOROBENZYL)SULFANYL]BENZOIC acid
Analyse Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3QCK
- Type
- protein
- Length
- 289 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor-type tyrosine-protein phosphatase gamma
- EC
- 3.1.3.48
- UniProt
- P23470
- Ligands
- NX5
- Pockets
- 1 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Receptor-type tyrosine-protein phosphatase gamma (EC 3.1.3.48) | protein | 289 | 37% helix, 24% strand | P23470 |
Ligands and binding sites
- NX5 · 2-[(3,4-dichlorobenzyl)sulfanyl]benzoic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 242 | 0.64 | 0.82 | 35 | NX5 |
Compared structures
- 3QCK · Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P23470 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase gamma… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23470
- Elsewhere: RCSB PDB 3QCK · PDBe 3QCK · UniProt P23470
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