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Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with N-[(3-AMINOPHENYL)SULFONYL]-3-[(3,4-dichlorobenzyl) SULFANYL]THIOPHENE-2-carboxamide

Analyse Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3QCI
Type: protein
Length: 285 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Receptor-type tyrosine-protein phosphatase gamma
EC: 3.1.3.48
UniProt: P23470
Ligands: NX3
Pockets: 1 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Receptor-type tyrosine-protein phosphatase gamma (EC 3.1.3.48)	protein	285	36% helix, 22% strand	P23470

Ligands and binding sites

NX3 · N-[(3-aminophenyl)sulfonyl]-3-[(3,4-dichlorobenzyl)sulfanyl]thiophene-2-carboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	226	0.63	0.82	34	NX3

Compared structures

3QCI · Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
P23470 · AlphaFold monomer V2.0 prediction for receptor-type tyrosine-protein phosphatase gamma… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P23470
Elsewhere: RCSB PDB 3QCI · PDBe 3QCI · UniProt P23470

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