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Beta-lactam-sensor domain of BLAR1 (apo) from staphylococcus aureus with carboxylated LYS392

Analyse Beta-lactam-sensor domain of BLAR1 (apo) from staphylococcus aureus with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3Q7V
Type: protein
Length: 504 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-lactamase regulatory protein BLAR1
UniProt: Q7WU28
Ligands: SO4
Pockets: 2 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Beta-lactamase regulatory protein BLAR1	protein	252	36% helix, 25% strand	Q7WU28

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A, B
GOL · Glycerol · additive · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	992	0.77	0.80	94	GOL
2	113	0.38	0.74	26	empty

Interfaces

1 interface between chains.

A–B · 574 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (carboxylation).

Compared structures

3Q7V · Beta-Lactam-Sensor Domain of BlaR1 (Apo) from Staphylococcus Aureus with Carboxylated… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7WU28
Elsewhere: RCSB PDB 3Q7V · PDBe 3Q7V · UniProt Q7WU28

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