Research workbench
X-ray crystal structure of protein MLL2253 from mesorhizobium loti, northeast structural genomics consortium target MLR404.
Analyse X-ray crystal structure of protein MLL2253 from mesorhizobium loti, northeast… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3Q63
- Type
- protein
- Length
- 816 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MLL2253 protein
- UniProt
- Q98IT8
- Pockets
- 10 · best druggability 0.69
Structure
x-ray diffraction · 5 distinct chains · 29% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MLL2253 protein | protein | 132 | 29% helix, 37% strand | Q98IT8 |
| B, C | MLL2253 protein | protein | 137 | 29% helix, 39% strand | Q98IT8 |
| D | MLL2253 protein | protein | 136 | 29% helix, 38% strand | Q98IT8 |
| E | MLL2253 protein | protein | 135 | 29% helix, 37% strand | Q98IT8 |
| F | MLL2253 protein | protein | 139 | 29% helix, 40% strand | Q98IT8 |
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 466 | 0.69 | 0.80 | 60 | empty |
| 2 | 357 | 0.63 | 0.79 | 42 | empty |
| 3 | 314 | 0.62 | 0.79 | 37 | empty |
| 4 | 385 | 0.61 | 0.77 | 31 | empty |
| 5 | 352 | 0.59 | 0.76 | 29 | empty |
Interfaces
8 interfaces between chains.
- C–D · 1117 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 1021 Ų buried · 16 hydrogen bonds · protein-protein
- E–F · 998 Ų buried · 12 hydrogen bonds · protein-protein
- A–F · 550 Ų buried · 6 hydrogen bonds · protein-protein
- D–E · 507 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
- 3Q63 · X-ray crystal structure of protein MLL2253 from Mesorhizobium loti, Northeast Structural… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q98IT8
- Elsewhere: RCSB PDB 3Q63 · PDBe 3Q63 · UniProt Q98IT8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.