Research workbench
Crystal structure of a serine dehydrogenase from pseudomonas aeruginosa PAO1 in complex with NAD
Analyse Crystal structure of a serine dehydrogenase from pseudomonas aeruginosa PAO1 in… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3Q3C
- Type
- protein
- Length
- 294 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable 3-hydroxyisobutyrate dehydrogenase
- EC
- 1.1.1.276
- UniProt
- Q9I5I6
- Ligands
- NAD
- Pockets
- 1 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.276) | protein | 294 | 52% helix, 14% strand | Q9I5I6 |
Ligands and binding sites
- NAD · Nicotinamide-adenine-dinucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 370 | 0.65 | 0.79 | 40 | NAD |
Modifications
Observed in the structure: 13 modified (engineered).
Compared structures
- 3Q3C · Crystal structure of a serine dehydrogenase from Pseudomonas aeruginosa pao1 in complex… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9I5I6 · AlphaFold monomer V2.0 prediction for NAD-dependent L-serine dehydrogenase (Q9I5I6) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9I5I6
- Elsewhere: RCSB PDB 3Q3C · PDBe 3Q3C · UniProt Q9I5I6
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