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Crystal structure of the second bromodomain of human bromodomain and wd repeat-containing protein 1 isoform a (WDR9)

Analyse Crystal structure of the second bromodomain of human bromodomain and wd… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3Q2E
Type: protein
Length: 107 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bromodomain and wd repeat-containing protein 1
UniProt: Q9NSI6
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 69% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bromodomain and wd repeat-containing protein 1	protein	107	69% helix, 0% strand	Q9NSI6

Ligands and binding sites

ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	89	0.46	0.80	18	ACT

Compared structures

3Q2E · Crystal structure of the second bromodomain of human bromodomain and WD repeat-containing… · the same entry in another collection · chain A against A, TM-score 1.00
Q9NSI6 · AlphaFold monomer V2.0 prediction for bromodomain and wd repeat- containing protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NSI6
Elsewhere: RCSB PDB 3Q2E · PDBe 3Q2E · UniProt Q9NSI6

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