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Crystal structure of the pumilio-homology domain from human PUMILIO2 in complex with P38ALPHA nreb

Analyse Crystal structure of the pumilio-homology domain from human PUMILIO2 in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3Q0R
Type: protein + RNA
Length: 351 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pumilio homolog 2; 5'-R(UP*GP*UP*AP*GP*AP*UP*A)-3'
UniProt: Q8TB72
Pockets: 1 · best druggability 0.33

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pumilio homolog 2	protein	343	72% helix, 0% strand	Q8TB72
B	5'-R(UPGPUPAPGPAPUP*A)-3'	rna	8	—	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	64	0.33	0.76	18	empty

Interfaces

1 interface between chains.

A–B · 1429 Å² buried · 55 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

3Q0R · Crystal structure of the PUMILIO-homology domain from Human PUMILIO2 in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Q8TB72 · AlphaFold monomer V2.0 prediction for pumilio homolog 2 (Q8TB72) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TB72
Elsewhere: RCSB PDB 3Q0R · PDBe 3Q0R · UniProt Q8TB72

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