Research workbench

The crystal structure of aaleurs-CP1-D20

Analyse The crystal structure of aaleurs-CP1-D20 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3PZ5
Type: protein
Length: 383 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Leucyl-tRNA synthetase subunit alpha
EC: 6.1.1.4
UniProt: O66680
Pockets: 4 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Leucyl-tRNA synthetase subunit alpha (EC 6.1.1.4)	protein	191	32% helix, 24% strand	O66680
B	Leucyl-tRNA synthetase subunit alpha (EC 6.1.1.4)	protein	192	32% helix, 23% strand	O66680

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	237	0.58	0.79	24	empty
2	224	0.56	0.79	24	empty
3	250	0.53	0.76	39	empty
4	51	0.25	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 214 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

3PZ5 · The crystal structure of AaLeuRS-CP1-D20 · the same entry in another collection · chain A against A, TM-score 1.00
O66680 · AlphaFold monomer V2.0 prediction for leucine--tRNA ligase subunit alpha (O66680) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O66680
Elsewhere: RCSB PDB 3PZ5 · PDBe 3PZ5 · UniProt O66680

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.