Research workbench
Crystal structure of the MUNC18-1 and SYNTAXIN4 N-peptide complex
Analyse Crystal structure of the MUNC18-1 and SYNTAXIN4 N-peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3PUJ
- Type
- protein
- Length
- 1,086 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Syntaxin-binding protein 1; Syntaxin-4 N-terminal peptide
- UniProt
- P61765, P70452
- Pockets
- 18 · best druggability 0.62
Structure
x-ray diffraction · 4 distinct chains · 50% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Syntaxin-binding protein 1 | protein | 533 | 50% helix, 15% strand | P61765 |
| C | Syntaxin-4 N-terminal peptide | protein | 9 | 56% helix, 11% strand | P70452 |
| B | Syntaxin-binding protein 1 | protein | 534 | 50% helix, 14% strand | P61765 |
| D | Syntaxin-4 N-terminal peptide | protein | 10 | 40% helix, 0% strand | P70452 |
Pockets
18 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 368 | 0.62 | 0.77 | 45 | empty |
| 2 | 72 | 0.60 | 0.89 | 24 | empty |
| 3 | 293 | 0.60 | 0.78 | 42 | empty |
| 4 | 226 | 0.57 | 0.78 | 34 | empty |
| 5 | 223 | 0.55 | 0.78 | 37 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1422 Ų buried · 11 hydrogen bonds · protein-protein
- A–C · 563 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 552 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 3PUJ · Crystal structure of the MUNC18-1 and SYNTAXIN4 N-Peptide complex · the same entry in another collection · chain D against D, TM-score 1.00
- P61765 · AlphaFold monomer V2.0 prediction for syntaxin-binding protein 1 (P61765) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P70452 · AlphaFold monomer V2.0 prediction for syntaxin-4 (P70452) · a predicted model of the same protein · chain C against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61765
- Every structure of UniProt P70452
- Elsewhere: RCSB PDB 3PUJ · PDBe 3PUJ · UniProt P61765 · UniProt P70452
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