Research workbench

V369M mutant of glutamyl-tRNA synthetase from mycobacterium tuberculosis

Analyse V369M mutant of glutamyl-tRNA synthetase from mycobacterium tuberculosis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3PNV
Type: protein
Length: 966 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamyl-tRNA synthetase
EC: 6.1.1.17
UniProt: P0A636
Pockets: 9 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 50% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamyl-tRNA synthetase (EC 6.1.1.17)	protein	481	52% helix, 11% strand	P0A636
B	Glutamyl-tRNA synthetase (EC 6.1.1.17)	protein	485	49% helix, 12% strand	P0A636

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	551	0.70	0.79	46	empty
2	589	0.67	0.77	56	empty
3	413	0.66	0.79	40	empty
4	386	0.56	0.74	24	empty
5	141	0.43	0.75	27	empty

Interfaces

1 interface between chains.

A–B · 832 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

3PNV · V369M mutant of Glutamyl-tRNA synthetase from Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A636
Elsewhere: RCSB PDB 3PNV · PDBe 3PNV · UniProt P0A636

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