Research workbench
Crystal structure analysis of rabbit phosphoglucose isomerase complexed with 5-phosphoarabinonate, a transition state analogue
Analyse Crystal structure analysis of rabbit phosphoglucose isomerase complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1G98
- Type
- protein
- Length
- 1,110 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoglucose isomerase
- EC
- 5.3.1.9
- UniProt
- Q9N1E2
- Ligands
- PA5
- Pockets
- 10 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 54% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Phosphoglucose isomerase (EC 5.3.1.9) | protein | 555 | 54% helix, 13% strand | Q9N1E2 |
Ligands and binding sites
- PA5 · 5-phosphoarabinonic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1053 | 0.78 | 0.80 | 60 | empty |
| 2 | 388 | 0.73 | 0.84 | 60 | PA5 |
| 3 | 175 | 0.71 | 0.89 | 37 | PA5 |
| 4 | 132 | 0.46 | 0.77 | 16 | empty |
| 5 | 98 | 0.42 | 0.78 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 6378 Ų buried · 96 hydrogen bonds · protein-protein
Compared structures
- 1G98 · Crystal structure analysis of rabbit phosphoglucose isomerase complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9N1E2 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate isomerase (Q9N1E2) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9N1E2
- Elsewhere: RCSB PDB 1G98 · PDBe 1G98 · UniProt Q9N1E2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.