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The crystal structure of TP34 bound to ZN(II) ion at pH 7.5
Analyse The crystal structure of TP34 bound to ZN(II) ion at pH 7.5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3PJN
- Type
- protein
- Length
- 315 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 34 kda membrane antigen
- UniProt
- P19478
- Ligands
- ZN, SO4
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 34 kda membrane antigen | protein | 158 | 4% helix, 46% strand | P19478 |
| B | 34 kda membrane antigen | protein | 157 | 4% helix, 46% strand | P19478 |
Ligands and binding sites
- ZN · Zinc ion · metal · 15 copies · chains A, B
- SO4 · Sulfate ion · ion · chains A
- EDO · 1,2-ethanediol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 247 | 0.50 | 0.75 | 51 | empty |
| 2 | 97 | 0.42 | 0.78 | 29 | ZN |
Interfaces
1 interface between chains.
- A–B · 1744 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19478
- Elsewhere: RCSB PDB 3PJN · PDBe 3PJN · UniProt P19478
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