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Solution structure of the PDZ2 domain from human phosphatase HPTP1E

Analyse Solution structure of the PDZ2 domain from human phosphatase HPTP1E in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3PDZ
Type: protein
Length: 96 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (tyrosine phosphatase (ptp-bas, type 1))
EC: 3.1.3.48
UniProt: Q12923
Pockets: 1 · best druggability 0.54

Structure

solution nmr · 1 distinct chain · 15% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (tyrosine phosphatase (ptp-bas, type 1)) (EC 3.1.3.48)	protein	96	15% helix, 30% strand	Q12923

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.54	0.86	18	empty

Compared structures

3PDZ · Solution structure of the PDZ2 domain from human phosphatase HPTP1E · the same entry in another collection · chain A against A, TM-score 1.00
Q12923 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 13… · a predicted model of the same protein · chain A against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12923
Elsewhere: RCSB PDB 3PDZ · PDBe 3PDZ · UniProt Q12923

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