Research workbench

X-ray structure of translation initiation factor IF2/EIF5B

Analyse X-ray structure of translation initiation factor IF2/EIF5B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1G7R
Type: protein
Length: 559 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Translation initiation factor IF2/EIF5B
UniProt: O26359
Pockets: 4 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Translation initiation factor IF2/EIF5B	protein	559	32% helix, 32% strand	O26359

Pockets

4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.44	0.80	18	empty
2	103	0.43	0.77	20	empty
3	95	0.36	0.74	23	empty
4	61	0.31	0.75	17	empty

Modifications

Observed in the structure: 17 modified (engineered).

Compared structures

1G7R · X-ray structure of translation initiation factor IF2/EIF5B · the same entry in another collection · chain A against A, TM-score 1.00
O26359 · AlphaFold monomer V2.0 prediction for probable translation initiation factor if-2 (O26359) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O26359
Elsewhere: RCSB PDB 1G7R · PDBe 1G7R · UniProt O26359

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