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Crystal structure of the NS1 effector domain W182A mutant from influenza A/VIETNAM/1203/2004 (H5N1) virus

Analyse Crystal structure of the NS1 effector domain W182A mutant from influenza… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3P38
Type: protein
Length: 365 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nonstructural protein 1
UniProt: D1LP63
Pockets: 3 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nonstructural protein 1	protein	123	25% helix, 38% strand	D1LP63
B, C	Nonstructural protein 1	protein	121	26% helix, 39% strand	D1LP63

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	449	0.62	0.76	46	empty
2	58	0.45	0.83	17	empty
3	56	0.23	0.71	15	empty

Interfaces

3 interfaces between chains.

A–B · 642 Å² buried · 8 hydrogen bonds · protein-protein
A–C · 436 Å² buried · 5 hydrogen bonds · protein-protein
B–C · 57 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

3P38 · Crystal structure of the NS1 effector domain W182A mutant from influenza… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt D1LP63
Elsewhere: RCSB PDB 3P38 · PDBe 3P38 · UniProt D1LP63

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