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Crystal structure of the ligand binding domain of human testicular receptor 4
Analyse Crystal structure of the ligand binding domain of human testicular receptor 4 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3P0U
- Type
- protein
- Length
- 438 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear receptor subfamily 2 group C member 2
- UniProt
- P49116
- Pockets
- 9 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nuclear receptor subfamily 2 group C member 2 | protein | 222 | 55% helix, 0% strand | P49116 |
| B | Nuclear receptor subfamily 2 group C member 2 | protein | 216 | 51% helix, 0% strand | P49116 |
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 398 | 0.69 | 0.81 | 56 | empty |
| 2 | 291 | 0.62 | 0.79 | 32 | empty |
| 3 | 105 | 0.59 | 0.86 | 23 | empty |
| 4 | 320 | 0.53 | 0.74 | 37 | empty |
| 5 | 80 | 0.51 | 0.84 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1400 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 3P0U · Crystal Structure of the ligand binding domain of human testicular receptor 4 · the same entry in another collection · chain A against A, TM-score 1.00
- P49116 · AlphaFold monomer V2.0 prediction for nuclear receptor subfamily 2 group C member 2… · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P49116
- Elsewhere: RCSB PDB 3P0U · PDBe 3P0U · UniProt P49116
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