Research workbench
Crystal structure of two-component response regulator from nostoc sp. pcc 7120
Analyse Crystal structure of two-component response regulator from nostoc sp. pcc 7120 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3P01
- Type
- protein
- Length
- 522 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Two-component response regulator
- UniProt
- Q8YLP5
- Pockets
- 6 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 46% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Two-component response regulator | protein | 178 | 51% helix, 22% strand | Q8YLP5 |
| B | Two-component response regulator | protein | 175 | 43% helix, 21% strand | Q8YLP5 |
| C | Two-component response regulator | protein | 169 | 44% helix, 24% strand | Q8YLP5 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 326 | 0.62 | 0.79 | 35 | empty |
| 2 | 57 | 0.42 | 0.82 | 14 | empty |
| 3 | 140 | 0.41 | 0.75 | 22 | empty |
| 4 | 109 | 0.41 | 0.76 | 20 | empty |
| 5 | 149 | 0.39 | 0.73 | 23 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1347 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 661 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 77 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 modified, 1 disulfide (engineered, disulfide).
Compared structures
- 3P01 · Crystal structure of two-component response regulator from Nostoc sp. PCC 7120 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8YLP5
- Elsewhere: RCSB PDB 3P01 · PDBe 3P01 · UniProt Q8YLP5
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