Research workbench
Crystal structure of the globular region of the prion protein URE2 from the yeast saccaromyces cerevisiae
Analyse Crystal structure of the globular region of the prion protein URE2 from the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1G6W
- Type
- protein
- Length
- 990 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- URE2 protein
- UniProt
- P23202
- Pockets
- 15 · best druggability 0.82
Structure
x-ray diffraction · 4 distinct chains · 60% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | URE2 protein | protein | 234 | 59% helix, 7% strand | P23202 |
| B | URE2 protein | protein | 242 | 60% helix, 7% strand | P23202 |
| C | URE2 protein | protein | 255 | 62% helix, 7% strand | P23202 |
| D | URE2 protein | protein | 259 | 61% helix, 7% strand | P23202 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 941 | 0.82 | 0.83 | 77 | empty |
| 2 | 572 | 0.73 | 0.81 | 40 | empty |
| 3 | 543 | 0.72 | 0.80 | 40 | empty |
| 4 | 535 | 0.71 | 0.80 | 38 | empty |
| 5 | 172 | 0.53 | 0.79 | 25 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2005 Ų buried · 27 hydrogen bonds · protein-protein
- C–D · 1928 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 596 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 1G6W · Crystal structure of the globular region of the prion protein URE2 from the yeast… · the same entry in another collection · chain D against D, TM-score 1.00
- P23202 · AlphaFold monomer V2.0 prediction for transcriptional regulator URE2 (P23202) · a predicted model of the same protein · chain D against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23202
- Elsewhere: RCSB PDB 1G6W · PDBe 1G6W · UniProt P23202
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