Research workbench

Endoglucanase I native structure

Analyse Endoglucanase I native structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3OVW
Type: protein
Length: 800 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Endoglucanase I
EC: 3.2.1.4
UniProt: P46237
Ligands: NAG
Pockets: 5 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Endoglucanase I (EC 3.2.1.4)	protein	400	16% helix, 35% strand	P46237

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	581	0.70	0.79	64	empty
2	564	0.69	0.78	64	empty
3	162	0.47	0.77	27	empty
4	153	0.44	0.76	18	empty
5	52	0.26	0.73	13	empty

Interfaces

1 interface between chains.

A–B · 484 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 18 disulfide, 4 glycan, 2 modified (disulfide, N-glycosylation, cyclization).

Compared structures

3OVW · Endoglucanase I native structure · the same entry in another collection · chain A against A, TM-score 1.00
P46237 · AlphaFold monomer V2.0 prediction for endoglucanase type C (P46237) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46237
Elsewhere: RCSB PDB 3OVW · PDBe 3OVW · UniProt P46237

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.