Research workbench
Crystal structure of the intracellular domain of RV3910 from mycobacterium tuberculosis
Analyse Crystal structure of the intracellular domain of RV3910 from mycobacterium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OTV
- Type
- protein
- Length
- 1,003 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable conserved transmembrane protein
- UniProt
- O05435
- Pockets
- 9 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 36% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable conserved transmembrane protein | protein | 254 | 37% helix, 21% strand | O05435 |
| B | Probable conserved transmembrane protein | protein | 244 | 36% helix, 22% strand | O05435 |
| C | Probable conserved transmembrane protein | protein | 257 | 33% helix, 20% strand | O05435 |
| D | Probable conserved transmembrane protein | protein | 248 | 36% helix, 21% strand | O05435 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 599 | 0.70 | 0.79 | 47 | empty |
| 2 | 552 | 0.65 | 0.76 | 41 | empty |
| 3 | 174 | 0.53 | 0.79 | 34 | empty |
| 4 | 117 | 0.42 | 0.76 | 24 | empty |
| 5 | 101 | 0.41 | 0.77 | 21 | empty |
Interfaces
4 interfaces between chains.
- A–C · 734 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 688 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 631 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 32 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3OTV · Crystal structure of the intracellular domain of Rv3910 from Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O05435
- Elsewhere: RCSB PDB 3OTV · PDBe 3OTV · UniProt O05435
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