Research workbench
Crystal structure of human trnahis guanylyltransferase (THG1) - dgtp complex
Analyse Crystal structure of human trnahis guanylyltransferase (THG1) - dgtp complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OTB
- Type
- protein
- Length
- 474 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA(HIS) guanylyltransferase
- EC
- 2.7.7.-
- UniProt
- Q9NWX6
- Ligands
- DGT, 3PO, MG
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | TRNA(HIS) guanylyltransferase (EC 2.7.7.-) | protein | 237 | 46% helix, 16% strand | Q9NWX6 |
Ligands and binding sites
- DGT · 2'-deoxyguanosine-5'-triphosphate · ligand · 2 copies · chains A, B
- 3PO · Triphosphate · ligand · 2 copies · chains A, B
- MG · Magnesium ion · metal · 6 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 325 | 0.66 | 0.81 | 29 | DGT |
| 2 | 296 | 0.65 | 0.81 | 29 | DGT |
| 3 | 260 | 0.56 | 0.77 | 32 | empty |
| 4 | 53 | 0.45 | 0.84 | 15 | empty |
| 5 | 53 | 0.41 | 0.82 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2098 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 3OTB · Crystal structure of human tRNAHis guanylyltransferase (Thg1) - dGTP complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9NWX6 · AlphaFold monomer V2.0 prediction for probable TRNA(HIS) guanylyltransferase (Q9NWX6) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWX6
- Elsewhere: RCSB PDB 3OTB · PDBe 3OTB · UniProt Q9NWX6
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.