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Crystal structure of an engineered cro monomer bound nonspecifically to DNA

Analyse Crystal structure of an engineered cro monomer bound nonspecifically to DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3ORC
Type: protein + DNA
Length: 81 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA (5'-D(*TP*AP*TP*CP*GP*AP*TP*A)-3'); Protein (cro repressor)
UniProt: P03040
Pockets: 1 · best druggability 0.41

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
R, S	DNA (5'-D(TPAPTPCPGPAPTPA)-3')	dna	8	—	—
A	Protein (cro repressor)	protein	65	40% helix, 28% strand	P03040

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	81	0.41	0.79	14	empty

Interfaces

3 interfaces between chains.

R–S · 371 Å² buried · 42 hydrogen bonds · nucleic-nucleic
S–A · 364 Å² buried · 8 hydrogen bonds · protein-nucleic
R–A · 166 Å² buried · 2 hydrogen bonds · protein-nucleic

Compared structures

3ORC · Crystal structure of an engineered cro monomer bound nonspecifically to DNA · the same entry in another collection · chain R against R, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03040
Elsewhere: RCSB PDB 3ORC · PDBe 3ORC · UniProt P03040

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