Research workbench
Structure of ccpa-hpr-SER46-P-gntr-down cre
Analyse Structure of ccpa-hpr-SER46-P-gntr-down cre in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OQN
- Type
- protein + DNA
- Length
- 870 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Catabolite control protein a; Phosphocarrier protein hpr…
- EC
- 2.7.11.-
- UniProt
- P25144, P08877
- Pockets
- 13 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 43% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Catabolite control protein a | protein | 332 | 46% helix, 15% strand | P25144 |
| S, D | Phosphocarrier protein hpr (EC 2.7.11.-) | protein | 87 | 33% helix, 21% strand | P08877 |
| E | 5'-D(*TP*TP*GP*AP*AP*AP*GP*CP*GP*GP*TP*AP*CP*CP*AP*T)-3' | dna | 16 | — | — |
| B | 5'-D(*AP*TP*GP*GP*TP*AP*CP*CP*GP*CP*TP*TP*TP*CP*AP*A)-3' | dna | 16 | — | — |
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 640 | 0.74 | 0.80 | 66 | empty |
| 2 | 643 | 0.73 | 0.80 | 64 | empty |
| 3 | 193 | 0.68 | 0.86 | 28 | empty |
| 4 | 212 | 0.56 | 0.79 | 31 | empty |
| 5 | 113 | 0.48 | 0.80 | 17 | empty |
Interfaces
10 interfaces between chains.
- A–C · 2237 Ų buried · 37 hydrogen bonds · protein-protein
- E–B · 705 Ų buried · 73 hydrogen bonds · nucleic-nucleic
- A–S · 699 Ų buried · 8 hydrogen bonds · protein-protein
- C–D · 661 Ų buried · 7 hydrogen bonds · protein-protein
- C–B · 583 Ų buried · 9 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 3OQN · Structure of ccpa-hpr-ser46-p-gntr-down cre · the same entry in another collection · chain B against B, TM-score 1.00
- P25144 · AlphaFold monomer V2.0 prediction for catabolite control protein a (P25144) · a predicted model of the same protein · chain C against A, TM-score 0.99
- P08877 · AlphaFold monomer V2.0 prediction for phosphocarrier protein hpr (P08877) · a predicted model of the same protein · chain S against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25144
- Every structure of UniProt P08877
- Elsewhere: RCSB PDB 3OQN · PDBe 3OQN · UniProt P25144 · UniProt P08877
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