Research workbench
Crystal structures and biochemical characterization of the bacterial solute receptor acbh reveal an unprecedented exclusive substrate preference for B-D-galactopyranose
Analyse Crystal structures and biochemical characterization of the bacterial solute… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OO9
- Type
- protein
- Length
- 790 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ABC transporter binding protein acbh
- UniProt
- Q27GR2
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | ABC transporter binding protein acbh | protein | 395 | 52% helix, 15% strand | Q27GR2 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 728 | 0.74 | 0.80 | 67 | SO4, GOL |
| 2 | 361 | 0.58 | 0.75 | 42 | SO4, GOL |
| 3 | 318 | 0.56 | 0.75 | 41 | GOL |
| 4 | 114 | 0.48 | 0.80 | 19 | empty |
| 5 | 155 | 0.47 | 0.77 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 557 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 3OO9 · Crystal structures and biochemical characterization of the bacterial solute receptor AcbH… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q27GR2
- Elsewhere: RCSB PDB 3OO9 · PDBe 3OO9 · UniProt Q27GR2
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