Research workbench
Crystal structure of the GLUK3 (GLUR7) atd dimer at 2.75 ångström resolution
Analyse Crystal structure of the GLUK3 (GLUR7) atd dimer at 2.75 ångström resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OLZ
- Type
- protein
- Length
- 743 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor, ionotropic kainate 3
- UniProt
- D3ZDH2
- Ligands
- NAG, CL
- Pockets
- 9 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor, ionotropic kainate 3 | protein | 372 | 35% helix, 23% strand | D3ZDH2 |
| B | Glutamate receptor, ionotropic kainate 3 | protein | 371 | 36% helix, 23% strand | D3ZDH2 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A, B
- CL · Chloride ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 837 | 0.82 | 0.85 | 76 | empty |
| 2 | 93 | 0.56 | 0.85 | 19 | empty |
| 3 | 112 | 0.51 | 0.82 | 22 | empty |
| 4 | 158 | 0.47 | 0.76 | 17 | empty |
| 5 | 71 | 0.36 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1649 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 glycan, 2 disulfide (N-glycosylation, disulfide).
Compared structures
- 3OLZ · Crystal structure of the GluK3 (GluR7) ATD dimer at 2.75 Angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt D3ZDH2
- Elsewhere: RCSB PDB 3OLZ · PDBe 3OLZ · UniProt D3ZDH2
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