Research workbench
Crystal structure of the human BACH2 poz domain, form II
Analyse Crystal structure of the human BACH2 poz domain, form II in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OHV
- Type
- protein
- Length
- 720 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription regulator protein BACH2
- UniProt
- Q9BYV9
- Pockets
- 10 · best druggability 0.71
Structure
x-ray diffraction · 5 distinct chains · 44% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcription regulator protein BACH2 | protein | 125 | 42% helix, 21% strand | Q9BYV9 |
| B | Transcription regulator protein BACH2 | protein | 121 | 45% helix, 21% strand | Q9BYV9 |
| C, E | Transcription regulator protein BACH2 | protein | 119 | 44% helix, 20% strand | Q9BYV9 |
| D | Transcription regulator protein BACH2 | protein | 117 | 44% helix, 21% strand | Q9BYV9 |
| F | Transcription regulator protein BACH2 | protein | 119 | 45% helix, 20% strand | Q9BYV9 |
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 822 | 0.71 | 0.76 | 79 | empty |
| 2 | 392 | 0.58 | 0.75 | 35 | empty |
| 3 | 275 | 0.57 | 0.77 | 39 | empty |
| 4 | 243 | 0.54 | 0.77 | 33 | empty |
| 5 | 69 | 0.53 | 0.86 | 19 | empty |
Interfaces
13 interfaces between chains.
- A–B · 2283 Ų buried · 29 hydrogen bonds · protein-protein
- E–F · 2159 Ų buried · 28 hydrogen bonds · protein-protein
- C–D · 1968 Ų buried · 27 hydrogen bonds · protein-protein
- A–C · 291 Ų buried · 1 hydrogen bond · protein-protein
- A–E · 251 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 3OHV · Crystal structure of the human Bach2 POZ domain, form II · the same entry in another collection · chain F against F, TM-score 1.00
- Q9BYV9 · AlphaFold monomer V2.0 prediction for transcription regulator protein BACH2 (Q9BYV9) · a predicted model of the same protein · chain D against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BYV9
- Elsewhere: RCSB PDB 3OHV · PDBe 3OHV · UniProt Q9BYV9
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