Research workbench
Crystal structure of hgprt from vibrio cholerae
Analyse Crystal structure of hgprt from vibrio cholerae in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OHP
- Type
- protein
- Length
- 667 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypoxanthine phosphoribosyltransferase
- EC
- 2.4.2.8
- UniProt
- Q9KUD7
- Pockets
- 7 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 24% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) | protein | 167 | 25% helix, 35% strand | Q9KUD7 |
| C | Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) | protein | 167 | 25% helix, 35% strand | Q9KUD7 |
| D | Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) | protein | 166 | 24% helix, 35% strand | Q9KUD7 |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 430 | 0.62 | 0.77 | 48 | empty |
| 2 | 376 | 0.60 | 0.77 | 42 | empty |
| 3 | 244 | 0.56 | 0.78 | 20 | empty |
| 4 | 338 | 0.55 | 0.75 | 33 | empty |
| 5 | 202 | 0.51 | 0.77 | 19 | empty |
Interfaces
4 interfaces between chains.
- A–B · 1404 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 1402 Ų buried · 17 hydrogen bonds · protein-protein
- A–C · 878 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 818 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3OHP · Crystal structure of HGPRT from Vibrio cholerae · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9KUD7
- Elsewhere: RCSB PDB 3OHP · PDBe 3OHP · UniProt Q9KUD7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.