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Crystal structure of the salmonella tyrosine phosphatase and GTPase activating protein sptp

Analyse Crystal structure of the salmonella tyrosine phosphatase and GTPase activating… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1G4W
Type: protein
Length: 341 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein tyrosine phosphatase sptp
UniProt: P74873
Pockets: 4 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
R	Protein tyrosine phosphatase sptp	protein	341	43% helix, 16% strand	P74873

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	244	0.58	0.79	27	empty
2	236	0.52	0.76	24	empty
3	56	0.38	0.81	16	empty
4	52	0.26	0.74	15	empty

Compared structures

1G4W · Crystal structure of the salmonella tyrosine phosphatase and GTPase activating protein… · the same entry in another collection · chain R against R, TM-score 1.00
P74873 · AlphaFold monomer V2.0 prediction for secreted effector protein sptp (P74873) · a predicted model of the same protein · chain R against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P74873
Elsewhere: RCSB PDB 1G4W · PDBe 1G4W · UniProt P74873

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