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Crystal structure of the TSG101 uev domain in complex with a human hrs psap peptide

Analyse Crystal structure of the TSG101 uev domain in complex with a human hrs psap… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3OBQ
Type
protein
Length
150 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Tumor susceptibility gene 101 protein; Hepatocyte growth factor-regulated tyrosine kinase…
UniProt
Q99816, O14964

Structure

x-ray diffraction · 2 distinct chains · 26% helix, 28% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ATumor susceptibility gene 101 proteinprotein14128% helix, 30% strandQ99816
BHepatocyte growth factor-regulated tyrosine kinase substrateprotein90% helix, 0% strandO14964

Interfaces

1 interface between chains.

  • A–B · 504 Ų buried · 6 hydrogen bonds · protein-protein

Compared structures

  • 3OBQ · Crystal Structure of the Tsg101 UEV domain in complex with a human HRS PSAP peptide · the same entry in another collection · chain A against A, TM-score 1.00
  • Q99816 · AlphaFold monomer V2.0 prediction for tumor susceptibility gene 101 protein (Q99816) · a predicted model of the same protein · chain A against A, TM-score 0.97
  • O14964 · AlphaFold monomer V2.0 prediction for hepatocyte growth factor- regulated tyrosine kinase… · a predicted model of the same protein · chain B against A, TM-score 0.43

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