Research workbench
Crystal structure of a SPN1 (IWS1)-SPT6 complex
Analyse Crystal structure of a SPN1 (IWS1)-SPT6 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3OAK
- Type
- protein
- Length
- 362 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcription factor IWS1; Transcription elongation factor SPT6
- UniProt
- Q06505, P23615
- Pockets
- 4 · best druggability 0.39
Structure
x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Transcription factor IWS1 | protein | 151 | 72% helix, 0% strand | Q06505 |
| C | Transcription elongation factor SPT6 | protein | 31 | 74% helix, 0% strand | P23615 |
| D | Transcription elongation factor SPT6 | protein | 29 | 66% helix, 0% strand | P23615 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.39 | 0.80 | 14 | empty |
| 2 | 100 | 0.38 | 0.75 | 17 | empty |
| 3 | 56 | 0.27 | 0.73 | 11 | empty |
| 4 | 51 | 0.26 | 0.73 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–D · 945 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 884 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 582 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3OAK · Crystal structure of a Spn1 (Iws1)-Spt6 complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q06505 · AlphaFold monomer V2.0 prediction for transcription factor SPN1 (Q06505) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P23615 · AlphaFold monomer V2.0 prediction for transcription elongation factor SPT6 (P23615) · a predicted model of the same protein · chain C against A, TM-score 0.46
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06505
- Every structure of UniProt P23615
- Elsewhere: RCSB PDB 3OAK · PDBe 3OAK · UniProt Q06505 · UniProt P23615
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