Research workbench
Crystal structure of cra transcriptional dual regulator from pseudomonas putida
Analyse Crystal structure of cra transcriptional dual regulator from pseudomonas putida in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3O74
- Type
- protein
- Length
- 541 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructose transport system repressor frur
- UniProt
- Q88PQ6
- Pockets
- 4 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fructose transport system repressor frur | protein | 270 | 42% helix, 23% strand | Q88PQ6 |
| B | Fructose transport system repressor frur | protein | 271 | 41% helix, 23% strand | Q88PQ6 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 798 | 0.78 | 0.82 | 86 | GOL |
| 2 | 122 | 0.52 | 0.81 | 20 | empty |
| 3 | 139 | 0.52 | 0.80 | 21 | empty |
| 4 | 80 | 0.45 | 0.80 | 11 | empty |
Interfaces
1 interface between chains.
- A–B · 1877 Ų buried · 31 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 3O74 · Crystal structure of Cra transcriptional dual regulator from Pseudomonas putida · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q88PQ6
- Elsewhere: RCSB PDB 3O74 · PDBe 3O74 · UniProt Q88PQ6
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