Research workbench
Crystal structures of the hslvu peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism
Analyse Crystal structures of the hslvu peptidase-ATPase complex reveal an… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1G4B
- Type
- protein
- Length
- 2,264 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent hsl protease ATP-binding subunit hslu; ATP-dependent protease hslv
- EC
- 3.4.99.-
- UniProt
- P0A6H5, P0A7B8
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 53% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, F, K, L | ATP-dependent hsl protease ATP-binding subunit hslu | protein | 393 | 61% helix, 10% strand | P0A6H5 |
| M, N, O, P | ATP-dependent protease hslv (EC 3.4.99.-) | protein | 173 | 35% helix, 30% strand | P0A7B8 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1164 | 0.86 | 0.87 | 135 | empty |
| 2 | 1133 | 0.83 | 0.84 | 105 | empty |
| 3 | 774 | 0.77 | 0.81 | 74 | empty |
| 4 | 719 | 0.72 | 0.78 | 87 | empty |
| 5 | 752 | 0.70 | 0.77 | 87 | empty |
Interfaces
13 interfaces between chains.
- E–F · 2548 Ų buried · 66 hydrogen bonds · protein-protein
- K–L · 1396 Ų buried · 21 hydrogen bonds · protein-protein
- L–O · 684 Ų buried · 23 hydrogen bonds · protein-protein
- M–P · 609 Ų buried · 2 hydrogen bonds · protein-protein
- O–P · 576 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 1G4B · Crystal structures of the hslvu peptidase-ATPase complex reveal an ATP-dependent… · the same entry in another collection · chain P against P, TM-score 1.00
- P0A7B8 · AlphaFold monomer V2.0 prediction for ATP-dependent protease subunit hslv (P0A7B8) · a predicted model of the same protein · chain M against A, TM-score 0.98
- P0A6H5 · AlphaFold monomer V2.0 prediction for ATP-dependent protease ATPase subunit hslu (P0A6H5) · a predicted model of the same protein · chain E against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6H5
- Every structure of UniProt P0A7B8
- Elsewhere: RCSB PDB 1G4B · PDBe 1G4B · UniProt P0A6H5 · UniProt P0A7B8
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