Research workbench
The crystal structure of the gaf domain of a two-component sensor histidine kinase from bacillus halodurans to 2.45A
Analyse The crystal structure of the gaf domain of a two-component sensor histidine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3O5Y
- Type
- protein
- Length
- 289 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sensor protein
- EC
- 2.7.13.3
- UniProt
- Q9KFE5
- Pockets
- 2 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sensor protein (EC 2.7.13.3) | protein | 142 | 33% helix, 27% strand | Q9KFE5 |
| B | Sensor protein (EC 2.7.13.3) | protein | 147 | 34% helix, 25% strand | Q9KFE5 |
Ligands and binding sites
- ACT · Acetate ion · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.39 | 0.80 | 14 | empty |
| 2 | 62 | 0.30 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 452 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 3O5Y · The Crystal Structure of the GAF domain of a two-component sensor histidine kinase from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9KFE5
- Elsewhere: RCSB PDB 3O5Y · PDBe 3O5Y · UniProt Q9KFE5
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