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Crystal structure of shikimate kinase from arabidopsis thaliana (ATSK2)

Analyse Crystal structure of shikimate kinase from arabidopsis thaliana (ATSK2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3NWJ
Type: protein
Length: 386 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATSK2
EC: 2.7.1.71
UniProt: Q8GY88
Pockets: 3 · best druggability 0.52

Structure

x-ray diffraction · 2 distinct chains · 65% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATSK2 (EC 2.7.1.71)	protein	194	65% helix, 11% strand	Q8GY88
B	ATSK2 (EC 2.7.1.71)	protein	192	65% helix, 11% strand	Q8GY88

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	248	0.52	0.76	46	empty
2	97	0.47	0.81	23	empty
3	109	0.37	0.74	27	empty

Interfaces

1 interface between chains.

A–B · 1228 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

3NWJ · Crystal structure of shikimate kinase from Arabidopsis thaliana (AtSK2) · the same entry in another collection · chain A against A, TM-score 1.00
Q8GY88 · AlphaFold monomer V2.0 prediction for shikimate kinase 2, chloroplastic (Q8GY88) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8GY88
Elsewhere: RCSB PDB 3NWJ · PDBe 3NWJ · UniProt Q8GY88

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