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Dimeric form of CTP synthase from sulfolobus solfataricus

Analyse Dimeric form of CTP synthase from sulfolobus solfataricus in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3NVA
Type: protein
Length: 1,066 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CTP synthase
EC: 6.3.4.2
UniProt: Q980S6
Pockets: 12 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	CTP synthase (EC 6.3.4.2)	protein	533	40% helix, 21% strand	Q980S6

Pockets

12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	618	0.72	0.80	70	empty
2	604	0.72	0.79	68	empty
3	281	0.63	0.81	36	empty
4	246	0.63	0.81	30	empty
5	121	0.46	0.78	20	empty

Interfaces

1 interface between chains.

A–B · 1518 Å² buried · 29 hydrogen bonds · protein-protein

Compared structures

3NVA · Dimeric form of CTP synthase from Sulfolobus solfataricus · the same entry in another collection · chain A against A, TM-score 1.00
Q980S6 · AlphaFold monomer V2.0 prediction for CTP synthase (Q980S6) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q980S6
Elsewhere: RCSB PDB 3NVA · PDBe 3NVA · UniProt Q980S6

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