Research workbench
Crystal structure of tetrameric rxralpha-lbd
Analyse Crystal structure of tetrameric rxralpha-lbd in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3NSP
- Type
- protein
- Length
- 383 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Retinoid X receptor, alpha
- UniProt
- Q2NL52
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Retinoid X receptor, alpha | protein | 193 | 68% helix, 2% strand | Q2NL52 |
| B | Retinoid X receptor, alpha | protein | 190 | 68% helix, 1% strand | Q2NL52 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 354 | 0.63 | 0.79 | 48 | empty |
| 2 | 229 | 0.57 | 0.78 | 24 | empty |
| 3 | 125 | 0.46 | 0.78 | 26 | empty |
| 4 | 80 | 0.38 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1111 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3NSP · Crystal structure of tetrameric RXRalpha-LBD · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2NL52
- Elsewhere: RCSB PDB 3NSP · PDBe 3NSP · UniProt Q2NL52
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