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Crystal structure of caspase-6 zymogen

Analyse Crystal structure of caspase-6 zymogen in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3NR2
Type: protein
Length: 463 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Caspase-6
EC: 3.4.22.59
UniProt: P55212
Pockets: 2 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Caspase-6 (EC 3.4.22.59)	protein	233	28% helix, 27% strand	P55212
B	Caspase-6 (EC 3.4.22.59)	protein	230	27% helix, 28% strand	P55212

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.57	0.90	17	empty
2	63	0.30	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 1561 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

3NR2 · Crystal structure of Caspase-6 zymogen · the same entry in another collection · chain A against A, TM-score 1.00
P55212 · AlphaFold monomer V2.0 prediction for caspase-6 (P55212) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55212
Elsewhere: RCSB PDB 3NR2 · PDBe 3NR2 · UniProt P55212

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